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In some studies, the 5-lipoxygenase inhibitor zileuton, when co-administered with PGE2, reduced pulmonary bacterial burden and pathology and prevented acute death in M.tb -infected mice deficient in both IL1R1 and IFNAR1 [129]

10.1007/s10571-019-00756-7 57 LiangY.YeC.ChenY.ChenY.DiaoS.HuangM

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21,22,23,24 Given the robust evidence for these conserved mechanisms, growing research attention is now directed towards the metabolic adaptations of neutrophils, 11,25,26 particularly how these immune cells remodel their metabolism in response to specific pathological microenvironments